Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coagulation01:06

Coagulation

1.3K
Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
1.3K
Coagulation01:09

Coagulation

9.8K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
9.8K
C4 Pathway and CAM01:27

C4 Pathway and CAM

48.9K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
48.9K
Multiple Allele Traits01:49

Multiple Allele Traits

38.0K
The Concept of Multiple Allelism
38.0K
Other Glycolytic Pathways01:24

Other Glycolytic Pathways

858
The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
858
Respiration Pathways01:26

Respiration Pathways

723
Cellular respiration is a fundamental metabolic process that enables organisms to generate energy from organic molecules. One of its central pathways is the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle, which plays a crucial role in energy production and biosynthetic processes.Conversion of Pyruvate to Acetyl-CoAThe pyruvate generated from glycolysis undergoes oxidative decarboxylation by the pyruvate dehydrogenase complex, producing acetyl-CoA, one molecule of NADH, and one...
723

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantifying cortical lesions in multiple sclerosis MRI datasets using multi-contrast post-processing and deep learning.

Communications medicine·2026
Same author

The impact of the COVID-19 pandemic on rabies control and health-seeking behavior for postexposure prophylaxis (PEP) in Serbia and North Macedonia and lessons learnt.

Scientific reports·2026
Same author

Immunogenic implications of translational readthrough modulate the association of F8 nonsense mutations with inhibitors in Hemophilia A.

Molecular medicine (Cambridge, Mass.)·2026
Same author

Underrecognized Tick-Borne Encephalitis in Serbia: Evidence from Patients with Suspected West Nile Virus Neuroinvasive Disease.

Pathogens (Basel, Switzerland)·2026
Same author

Zoonotic Relevance of <i>Toxocara</i> spp. in North Macedonia: Retrospective Veterinary Findings and a Clinically Confirmed Case of Human Ocular Toxocariasis.

Pathogens (Basel, Switzerland)·2026
Same author

Rational design of a novel engineered factor X with chimeric activation peptide as bypassing agent for hemophilia.

Journal of thrombosis and haemostasis : JTH·2026

Related Experiment Video

Updated: Jan 25, 2026

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
08:11

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

Published on: November 14, 2016

11.5K

Coagulation Pathways in Neurological Diseases: Multiple Sclerosis.

Nicole Ziliotto1,2, Francesco Bernardi1, Dejan Jakimovski2

  • 1Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.

Frontiers in Neurology
|May 10, 2019
PubMed
Summary
This summary is machine-generated.

Coagulation factors entering the brain in multiple sclerosis (MS) promote inflammation and neurodegeneration. Understanding these hemostasis pathways may reveal new therapeutic targets for MS treatment.

Keywords:
coagulationcoagulation inhibitorsextrinsic pathwayfibrinolytic pathwayintrinsic pathwaymultiple sclerosis

More Related Videos

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.7K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.0K

Related Experiment Videos

Last Updated: Jan 25, 2026

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
08:11

Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis

Published on: November 14, 2016

11.5K
The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.7K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

12.0K

Area of Science:

  • Neuroscience
  • Immunology
  • Hematology

Background:

  • Multiple Sclerosis (MS) involves blood-brain barrier (BBB) disruption, allowing coagulation factors into the central nervous system.
  • These factors trigger inflammation and immune responses, contributing to neurodegeneration in MS.

Purpose of the Study:

  • To review the complex interplay between hemostasis, inflammation, and autoimmunity in MS.
  • To highlight the role of coagulation factors and fibrinolysis in MS pathophysiology.
  • To discuss potential therapeutic targets based on these interactions.

Main Methods:

  • Review of existing literature on coagulation, fibrinolysis, and immune responses in MS.
  • Summary of histopathological findings, cerebrospinal fluid, plasma, and serum studies.
  • Discussion of disease-modifying treatments and autoimmunity in MS.

Main Results:

  • Fibrin(ogen) is a key contributor to neuroinflammation in MS.
  • Impaired fibrinolysis and fibrinogen deposition are hallmarks of progressive MS.
  • The immune-modulatory role of the intrinsic coagulation pathway in MS requires further elucidation.

Conclusions:

  • Coagulation system dysregulation significantly contributes to MS pathogenesis.
  • Further research into hemostasis components offers potential for novel MS therapies.
  • Targeting coagulation pathways could ameliorate MS progression.