Related Experiment Video
Updated: Jan 25, 2026
07:05
Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet
Published on: January 3, 2017
9.3K
Hyperhomocysteinemia as a Risk Factor and Potential Nutraceutical Target for Certain Pathologies
Caterina Tinelli1,2, Antonella Di Pino2, Elena Ficulle3
1Golgi Cenci Foundation, Abbiategrasso, Italy.
Frontiers in Nutrition
|May 10, 2019
Summary
Hyperhomocysteinemia, high homocysteine levels, is a risk factor for cardiovascular and neurological diseases. Supplementing with vitamins like folic acid and B12 may help manage this condition.
Area of Science:
- Biochemistry
- Metabolic pathways
- Disease pathogenesis
Background:
- Hyperhomocysteinemia (HHCys) is linked to cardiovascular and neurological diseases.
- Homocysteine (HCys) is a metabolite of methionine (Met), crucial for cellular functions.
- Enzyme dysregulation, often due to genetic polymorphisms, elevates HCys levels.
Purpose of the Study:
- To review pathological conditions associated with HHCys molecular pathways.
- To explore the role of HHCys in cardiovascular, neurological, and inflammatory diseases.
- To investigate potential management strategies for HHCys-related conditions.
Main Methods:
- Literature review of studies on HHCys and associated diseases.
- Analysis of molecular pathways involved in homocysteine metabolism.
- Examination of the impact of enzyme polymorphisms on HCys levels.
Main Results:
- Elevated HCys is a risk factor for atherosclerosis, stroke, Alzheimer's, and Parkinson's diseases.
- Genetic polymorphisms in metabolic enzymes are a primary cause of increased HCys.
- Vitamin supplementation (folic acid, B6, B12, betaine) shows potential in managing HHCys.
Conclusions:
- HHCys is a significant risk factor for multiple serious diseases.
- Understanding HHCys metabolism is key to disease prevention and treatment.
- Targeted vitamin supplementation offers a promising therapeutic approach for HHCys.
Related Concept Videos
01:26Factors Affecting the Risk of Infection
13.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.3K
01:12Relative Risk
2.0K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.0K
02:16Transcription Factors
82.3K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.3K
00:52Potential Energy
42.4K
The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
42.4K
04:01Factors Affecting Solubility
36.7K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
36.7K
03:02Standard Electrode Potentials
50.0K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.0K