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Updated: Jan 25, 2026
06:01
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
9.9K
Rationally engineered advances in cancer research.
Adam J Engler, Dennis E Discher1
1Biophysical Engineering Labs, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
APL Bioengineering
|May 10, 2019
Summary
Physical and engineering sciences offer novel approaches to cancer research. Innovations in microfluidics, imaging, and materials are improving cancer models and treatment strategies.
Area of Science:
- Physical Sciences
- Engineering Sciences
- Cancer Research
Background:
- Cancer research benefits from interdisciplinary approaches.
- Engineering and physical sciences offer tools for understanding cancer.
- Tumorigenesis and dissemination are complex processes.
Purpose of the Study:
- To highlight the contributions of physical and engineering sciences to cancer research.
- To showcase advancements in cancer diagnosis, understanding, and treatment.
- To emphasize the potential of engineering principles in developing novel cancer models.
Main Methods:
- Utilizing microfluidics, advanced imaging techniques, and novel materials.
- Employing micro-probes to measure tissue elasticity.
- Developing new measurement devices for biological analysis.
Main Results:
- Tissue elasticity influences epithelial-to-mesenchymal transition.
- Engineering approaches facilitate discoveries in cancer biology.
- Improved in vivo and in vitro cancer models are being developed.
Conclusions:
- Engineering and physical sciences are crucial for advancing cancer research.
- Interdisciplinary collaboration drives innovation in oncology.
- New tools and models enhance cancer understanding and treatment possibilities.
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