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Updated: Jan 25, 2026

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging
11:27

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

Published on: December 4, 2016

10.5K

[Magnetic resonance angiography without contrast agents]

M Bock1

  • 1Klinik für Radiologie - Medizin Physik, Universitätsklinikum Freiburg, Medizinische Fakultät, Universität Freiburg, Killianstr. 5a, 79106, Freiburg, Deutschland. michael.bock@uniklinik-freiburg.de.

Der Radiologe
|May 10, 2019
PubMed
Abstract

Insights

Minimize contrast agents in MR angiography by using native MRI techniques. These methods reliably visualize vessels like cerebral and coronary arteries, offering insights into blood flow dynamics.

Area of Science:

  • Radiology
  • Medical Imaging

Background:

  • Minimizing contrast agent use in Magnetic Resonance Imaging (MRI) angiography is crucial.
  • Exploring non-contrast enhanced techniques is a key research area.

Purpose of the Study:

  • To provide an overview of existing native MRI techniques for MR angiography.
  • To highlight the advantages of non-contrast enhanced angiography.

Main Methods:

  • Time-of-flight MRA: Utilizes the hyperintensity of unsaturated flowing blood.
  • Phase contrast MRA: Detects phase shifts induced by blood flow.
  • Arterial spin labeling: Dynamically images bolus passage via selective inversion.
  • Specialized MRI sequences: Leverage inherent blood contrast properties.

Main Results:

  • Native MRI angiography techniques can reliably delineate major vessels.
  • Demonstrated visualization of cerebral arteries and coronary arteries without contrast agents.
  • Provided additional valuable information regarding blood flow dynamics.

Conclusions:

  • Native MRI angiography is a reliable alternative to contrast-enhanced methods.
  • Proper selection of native techniques ensures accurate vessel delineation.
  • Offers comprehensive vascular and hemodynamic assessment.
Keywords:
Arterial spin labelingContrast mechanismsMagnetic resonance angiographyPhase contrastTime-of-flight

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