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Updated: Jan 25, 2026

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Modulation of CD95-mediated signaling by post-translational modifications: towards understanding CD95 signaling

Kamil Seyrek1, Inna N Lavrik2

  • 1Translational Inflammation Research, Institute of Experimental Internal Medicine, Medical Faculty, Otto von Guericke University, Magdeburg, Germany.

Apoptosis : an International Journal on Programmed Cell Death
|May 10, 2019
PubMed

Insights

CD95 receptor can trigger apoptosis or cell survival signals. This review explores how post-translational modifications of CD95 impact its function in cell death and cancer.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Cancer Research

Background:

  • CD95 (also known as Fas receptor) is a death receptor family member primarily known for inducing apoptosis.
  • Emerging evidence shows CD95 can also promote non-apoptotic signals, contributing to cell survival, proliferation, and cancer progression.
  • Research has largely focused on CD95 expression levels, with less attention paid to its post-translational modifications.

Purpose of the Study:

  • To review the role of post-translational modifications (PTMs) in CD95-mediated signaling.
  • To highlight how PTMs influence CD95's dual function in apoptosis and non-apoptotic pathways.
  • To emphasize the significance of PTMs in CD95-induced cell death and cancer development.

Main Methods:

  • Literature review focusing on studies investigating CD95 post-translational modifications.
  • Analysis of alterations in CD95 signaling pathways due to PTMs like glycosylation, phosphorylation, and others.
  • Synthesis of current knowledge on the impact of PTMs on CD95 function in mammalian systems.

Main Results:

  • Post-translational modifications significantly alter CD95 signaling outcomes.
  • PTMs can shift CD95 function from apoptosis induction to promoting cell survival and proliferation.
  • These modifications are crucial for understanding CD95's complex roles in cell death and cancer biology.

Conclusions:

  • Post-translational modifications play a critical, often underestimated, role in regulating CD95 function.
  • Understanding CD95 PTMs is essential for deciphering its involvement in both cell death and cancer.
  • Further research into CD95 PTMs could reveal novel therapeutic targets for cancer treatment.
Keywords:
CD95GlutathionylationGlycosylationNitrosylationPalmitoylationPhosphorylation

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