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B cell acute lymphoblastic leukemia (ALL) with a 14q+ chromosome abnormality
Blood
|February 1, 1979
Summary
This study presents a case of acute lymphoblastic leukemia (ALL) with a 14q+ marker chromosome, identifying the leukemic cells as B cells. The findings suggest a potential association between the 14q+ abnormality and B cell neoplasms.
Area of Science:
- Hematology
- Cytogenetics
- Oncology
Background:
- Acute lymphoblastic leukemia (ALL) is a heterogeneous lymphoid malignancy.
- Chromosomal abnormalities are common in ALL and can influence prognosis.
- The 14q+ marker chromosome is a rare finding in ALL.
Observation:
- A case of adult ALL with a 14q+ marker chromosome, resulting from an 11;14 translocation, is described.
- Leukemic cells were characterized as B cells based on surface markers and low adenosine deaminase activity.
- Only one other case of B cell ALL with a 14q+ chromosome has been reported in cytogenetic studies.
Findings:
- The presented case and one prior report represent the only documented instances of B cell ALL with chromosome banding analysis and a 14q+ marker.
- A higher frequency of the 14q+ chromosome in other B cell lymphoproliferative diseases suggests a potential link.
Implications:
- Cytogenetic analysis, including the 14q+ marker, may aid in classifying ALL subtypes.
- This association could refine our understanding of chromosomal abnormalities in B cell neoplasms.
- Further research may elucidate the role of the 14q+ abnormality in lymphoproliferative disorders.