Beneficial Effects of Rhodiola and Salidroside in Diabetes: Potential Role of AMP-Activated Protein Kinase
Tao Zheng1, Fang Bian2, Li Chen1
1Institute of Wudang Traditional Chinese Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China.
Abstract:
Diabetes mellitus represents a chronic metabolic disorder characterized by impaired lipid homeostasis and carbohydrate metabolism, gradually leading to persistent hyperglycemia. The extracts of Rhodiola species are widely used as herbal medicine or dietary supplement in Asia, Europe and the United States. Salidroside, a p-hydroxyphenethyl-β-glucoside compound, is the main active ingredient of the Rhodiola root. Recently, various studies have suggested that Rhodiola and salidroside may have pharmacological properties that could be used in the treatment of diabetes, as studies have confirmed that AMP-activated protein kinase (AMPK) and AMPK-related signaling are connected with its beneficial effects. This review aims to summarize the research progress of Rhodiola and salidroside in the treatment of diabetes. A detailed summary of AMPK and AMPK-related signaling induced by Rhodiola and salidroside are discussed.
Related Concept Videos
Protein Kinases and Phosphatases
Protein kinases
Many proteins in the cell are regulated by phosphorylation, the addition of a phosphate group. A family of enzymes called kinases...
Protein Kinases and Phosphatases
cAMP-dependent Protein Kinase Pathways
Cascaded Op Amps
In a cascaded system, each op-amp is referred to as a stage. The output of one stage drives the input of the subsequent stage. As the input signal passes through...
Second-order Op Amp Circuits
The analysis of such circuits follows a systematic approach, similar to the second-order RLC circuits. In practical scenarios, bulky inductors are rarely employed due to their size and weight. This means...
Role of Proteins in the Human Body


