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Cyclodextrins as Chiral Selectors in Capillary Electrophoresis Enantioseparations
Gerhard K E Scriba1, Pavel Jáč2
1Department of Pharmaceutical Chemistry, University of Jena, Jena, Germany.
Abstract:
Due to their structural variability and their commercial availability, cyclodextrins are the most frequently used chiral selectors in capillary electrophoresis. A variety of migration modes can be realized depending on the characteristics of the cyclodextrins and the analytes. The basic considerations regarding the development of a chiral CE method employing cyclodextrins as chiral selectors are briefly discussed. The presented examples illustrate the separation modes of an acidic and a basic analyte with native and charged cyclodextrin derivatives as a function of the pH of the background electrolyte and the concentration of the cyclodextrin.
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