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Updated: Jan 25, 2026

Development of a 68Gallium-Labeled D-Peptide PET Tracer for Imaging Programmed Death-Ligand 1 Expression
Published on: February 3, 2023
Preparation of a Dithiol-Reactive Probe for PET Imaging of Cell Death
Ivan Ho Shon1,2,3, Michael P Gotsbacher4, Jennifer Guille5
1Department of Nuclear Medicine and PET, Prince of Wales Hospital, Randwick, NSW, Australia. i.hoshon@unsw.edu.au.
Abstract:
Conjugates of 4-(N-(S-glutathionylacetyl)amino)phenylarsonous acid (GSAO) with optical or radionuclide probes are able to image cell death in vivo. GSAO conjugates are retained in the cytosol of dying and dead cells via the formation of covalent bonds between the As(III) ion and the thiol groups of proximal cysteine residues. Here we describe the method for preparing a NODAGA-GSAO conjugate and its radiolabeling with gallium-68 (68Ga-NODAGA-GSAO) for positron-emission tomography (PET) imaging of cell death.
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