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Update on diagnostic testing for platelet function disorders: What is practical and useful?

Catherine P M Hayward1,2,3, Karen A Moffat2,3, Justin Brunet1

  • 1Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

International Journal of Laboratory Hematology
|May 10, 2019
PubMed
Summary
This summary is machine-generated.

Diagnosing platelet function disorders (PFD) requires validated lab tests. Current PFD testing faces challenges due to evidence gaps and resource limits, impacting laboratory offerings.

Keywords:
hemostasislaboratory practicemolecular diagnosisplatelet functionquality controlvon Willebrand disease

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Area of Science:

  • Hematology
  • Clinical Pathology
  • Diagnostic Laboratory Science

Background:

  • Platelet function disorders (PFD) represent a significant category of bleeding disorders.
  • Effective diagnosis necessitates validated and practical laboratory testing strategies.

Purpose of the Study:

  • To review current practices in diagnostic laboratories offering PFD tests.
  • To evaluate laboratory experiences, existing literature, and international survey data on PFD diagnostics.

Main Methods:

  • Literature review
  • Analysis of international survey data on PFD testing practices
  • Evaluation of laboratory experiences

Main Results:

  • Commonly used PFD tests include blood counts, blood film review, and aggregation tests.
  • Platelet aggregation assays and dense granule number analysis show promise for detecting bleeding risks.
  • Lumiaggregometry exhibits variability, limiting its diagnostic utility. Resource and evidence limitations affect test menu expansion.

Conclusions:

  • Investigating PFD remains a challenge for diagnostic laboratories.
  • While some PFD tests are validated, evidence gaps and resource constraints influence test availability.
  • Further research and resources are needed to improve PFD diagnostic capabilities.