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Related Experiment Video

Updated: Jan 25, 2026

Co-culture of Living Microbiome with Microengineered Human Intestinal Villi in a Gut-on-a-Chip Microfluidic Device

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Published on: August 30, 2016

Veterinary ocular microbiome: Lessons learned beyond the culture.

Kayla C Banks¹, Aaron C Ericsson², Carol R Reinero¹

¹Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, Missouri.

Veterinary Ophthalmology

|May 10, 2019

Summary

The ocular surface harbors a diverse microbiome, largely undetected by traditional culture methods. Advanced sequencing reveals these microbes are crucial for eye health and disease management.

Keywords:

16S rRNA sequencing culture-independent methods high-throughput sequencing microbiome ocular pathogens

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Published on: October 19, 2014

Area of Science:

Ophthalmology
Microbiology
Microbiome research

Background:

Ocular pathogens cause severe eye diseases like keratitis and uveitis.
Traditional culture methods fail to detect many ocular microbes, leading to an incomplete understanding of the ocular surface microbiome.
The mammalian microbiome plays a vital role in host health and infection susceptibility.

Purpose of the Study:

To review the characteristics of the ocular surface microbiome.
To highlight the impact of molecular techniques on understanding ocular microbial communities.
To explore future applications in veterinary and human ophthalmology.

Main Methods:

Review of existing literature on ocular surface microbiology.
Discussion of high-throughput sequencing technologies for microbial identification.
Analysis of the limitations of traditional culture techniques.

Main Results:

The ocular surface hosts a more diverse microbial community than previously recognized.
Molecular techniques reveal a complex ocular microbiome previously missed by culturing.
Dysbiosis, an alteration in the microbiome, is linked to various disease states.

Conclusions:

High-throughput sequencing has revolutionized the study of the ocular surface microbiome.
Understanding the ocular microbiome is essential for managing infectious and inflammatory eye diseases.
Future research should focus on characterizing veterinary ocular microbiomes and their clinical relevance.