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[Axitinib in real life, analysis of our results.]

Clemencia Varilla-Varilla1, Fernando Vázquez Alonso2, Casandra Hernández Hernández2

  • 1Servicio de Urología. Hospital San Pedro Alcantara. Cáceres. España.

Archivos Espanoles De Urologia
|May 10, 2019
PubMed
Abstract

Insights

Axitinib demonstrated improved progression-free survival in metastatic renal carcinoma patients after first-line treatment. While toxicities were common, they were generally manageable, supporting its role in sequential therapy.

Area of Science:

  • Oncology
  • Pharmacology
  • Clinical Medicine

Background:

  • Metastatic renal carcinoma (mRCC) presents treatment challenges after first-line therapy.
  • Axitinib is an available option for second-line treatment in mRCC.
  • Real-world effectiveness and safety data for axitinib are crucial for clinical decision-making.

Purpose of the Study:

  • To evaluate the real-world effectiveness and safety of axitinib in metastatic renal carcinoma patients.
  • To analyze progression-free survival (PFS) and overall survival (OS) with axitinib treatment.
  • To assess the toxicity profile of axitinib in a clinical setting.

Main Methods:

  • Retrospective study of 16 patients with metastatic renal carcinoma treated with axitinib.
  • Patients received axitinib as second-line therapy after progression on sunitinib or pazopanib.
  • Effectiveness (PFS, OS) and safety (toxicity) were analyzed.

Main Results:

  • Median progression-free survival (PFS) was 9 months.
  • Median overall survival (OS) was 59 months among 8 deceased patients.
  • Common toxicities included diarrhea (87.5%), asthenia (75%), and dysphonia (56.25%), mostly grade 1-2 and manageable.

Conclusions:

  • Axitinib can increase PFS in metastatic renal carcinoma patients post-first-line progression.
  • Axitinib exhibits a tolerable toxicity profile in real-world practice.
  • The optimal role of axitinib in sequential therapy requires further definition with newer agents available.
Keywords:
Adverse effectsAxitinibCarcinoma de células renalesEfectos adversosInhibidores de la tirosin kinasaRenal cell carcinomaSecond lineSegunda líneaSequential therapyTerapia secuencialTyrosine kinase inhibitors

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