Related Experiment Video

Updated: Jan 25, 2026

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
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How does methylphenidate affect default mode network? A systematic review

P H Santos1, R Goncalves1, S Pedroso1

  • 1Hospital Pediatrico de Coimbra, 3000 Coimbra, Portugal.

Revista De Neurologia
|May 10, 2019
PubMed
Abstract

Insights

Methylphenidate may improve default mode network (DMN) dysfunction in attention deficit/hyperactivity disorder (ADHD) and related disorders. This medication appears to normalize brain circuits, potentially enhancing task performance in affected individuals.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • Attention deficit/hyperactivity disorder (ADHD) and other neuropsychiatric disorders are linked to default mode network (DMN) dysfunction.
  • DMN activity is typically attenuated during task execution and anticorrelated with task-positive networks in healthy individuals.
  • Methylphenidate is a common treatment, hypothesized to normalize DMN deactivation and improve task performance.

Purpose of the Study:

  • To systematically review the literature on methylphenidate's effects on DMN activity.
  • To explore the hypothesis that methylphenidate administration normalizes DMN deactivation.

Main Methods:

  • A systematic literature search was conducted.
  • Studies were included if they measured methylphenidate's impact on DMN activity.

Main Results:

  • Twelve studies met the eligibility criteria for the review.
  • Eleven studies indicated methylphenidate administration led to improvements in DMN-related brain areas.
  • Findings suggest a normalization of brain circuits in individuals with DMN dysfunction.

Conclusions:

  • Preliminary findings support methylphenidate's efficacy in improving DMN dysfunction in ADHD and other neuropsychiatric conditions.
  • Further research is necessary to fully elucidate methylphenidate's mechanisms of action on DMN.

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