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Updated: Jan 25, 2026

Robotic Enucleation of an Intra-Pancreatic Insulinoma in the Pancreatic Head
Published on: January 3, 2020
Exendin-4 analogs in insulinoma theranostics
Tom J P Jansen1, Sanne A M van Lith1, Marti Boss1
1Department of Radiology and Nuclear Medicine, Radboudumc, Nijmegen, The Netherlands.
Abstract:
Insulinomas, neuroendocrine tumors arising from pancreatic beta cells, often show overexpression of the glucagon-like peptide-1 receptor. Therefore, imaging with glucagon-like peptide analog exendin-4 can be used for diagnosis and preoperative localization. This review presents an overview of the development and clinical implementation of exendin-based tracers for nuclear imaging, and the potential use of exendin-4 based tracers for optical imaging and therapeutic applications such as peptide receptor radionuclide therapy or targeted photodynamic therapy.
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