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Updated: Jan 25, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
[Lower extremity artery disease. Angioplasty and stenting in 2019.]
M Sprynger1, P Maréchal1, M Moonen1
1Service de Cardiologie , CHU Liège, Belgique.
Insights
Lower extremity artery disease (LEAD) requires prompt detection and multidisciplinary management. Optimal care involves considering patient factors, pathology, and team expertise for effective treatment, including endovascular techniques and surgery.
Area of Science:
- Vascular Medicine
- Cardiovascular Surgery
Background:
- Lower extremity artery disease (LEAD) is a prevalent and often overlooked condition.
- Endovascular techniques have significantly advanced LEAD management, though vascular surgery remains crucial in specific scenarios.
- Management decisions require careful consideration of patient-specific factors, disease characteristics, and available expertise due to a lack of comparative trials.
Purpose of the Study:
- To highlight the importance of early detection and optimal management of LEAD.
- To emphasize the role of a multidisciplinary team in addressing the complexities of LEAD.
- To underscore the significant cardiovascular and amputation risks associated with LEAD, particularly chronic limb-threatening ischemia.
Main Methods:
- Review of current endovascular techniques and surgical interventions for LEAD.
- Discussion of parameters influencing treatment choices, including patient comorbidities and disease severity.
- Emphasis on the collaborative approach involving various medical specialists.
Main Results:
- Endovascular techniques offer revolutionary management options for LEAD.
- Vascular surgery is indicated in select cases, sometimes in hybrid procedures with angioplasty-stenting.
- Optimal management necessitates a multidisciplinary team approach, integrating medical treatment, prevention, and exercise.
Conclusions:
- Early detection and comprehensive management by a multidisciplinary team are essential for patients with LEAD.
- Patients with LEAD face high risks of cardiovascular events and amputation, demanding swift and optimal intervention.
- Integrated care, including medical therapy, lifestyle modifications, and timely revascularization, is paramount for improving outcomes in LEAD.
Abstract:
Lower extremity artery disease (LEAD) is frequent and too often neglected. The ongoing evolution of endovascular techniques has revolutionised its management. Vascular surgery is still recommended in specific clinical situations. It can be performed alone or combined with angioplasty-stenting in a hybrid procedure. Various parameters related to the patient, his pathology and to the medical team must be considered especially as randomized trials comparing devices and techniques are lacking. Technical progress should not mask the high cardiovascular morbi-mortality risk of these patients. Therefore LEAD must be detected as soon as possible and optimally managed by a multidisciplinary team. According to clinical stage and comorbidities, the team can include a general practitioner, an angiologist, a cardiologist, a nephrologist, a diabetologist, an oncologist, a radiologist, a vascular surgeon, a dermatologist, etc. Medical treatment of atherosclerosis and prevention are mandatory, as well as walking exercise. Due to its high cardiovascular and amputation risk, chronic limb-threatening ischemia must be quickly and optimally managed by a multidisciplinary team.
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