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Updated: Jan 25, 2026

Laboratory-determined Phosphorus Flux from Lake Sediments as a Measure of Internal Phosphorus Loading
Published on: March 6, 2014
Surface Coordination of Black Phosphorus with Modified Cisplatin.
Jianing Zhang1, Yue Ma1, Kuan Hu1
1State Key Laboratory of Chemical Oncogenomics, School of Chemical Biology and Biotechnology , Peking University Shenzhen Graduate School , Shenzhen 518055 , China.
This study stabilizes black phosphorus (BP) with modified cisplatin to create Pt@BP. This novel material enhances drug sensitivity in cisplatin-resistant cancer cells, offering potential for synergistic photothermal/chemotherapy.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Black phosphorus (BP) is a 2D nanomaterial with excellent electronic and optical properties.
- BP's susceptibility to oxidation limits its practical applications.
- Developing stable BP-based materials is crucial for advancing nanotechnology and medicine.
Purpose of the Study:
- To stabilize black phosphorus (BP) nanosheets against oxidation using a modified cisplatin complex.
- To investigate the potential of the stabilized material (Pt@BP) for cancer therapy.
- To evaluate the efficacy of Pt@BP in overcoming cisplatin resistance in cancer cell lines.
Main Methods:
- Surface coordination of black phosphorus (BP) nanosheets with modified cisplatin [Pt(NH3)2(NO3)2].
- Assessment of Pt@BP stability in ambient conditions.
- In vitro and cellular studies to evaluate DNA interaction, cellular uptake, and drug sensitivity of Pt@BP.
- Comparison of Pt@BP efficacy against cisplatin-resistant cancer cell lines (A2780 and HepG2) with unmodified cisplatin.
Main Results:
- Pt@BP demonstrated remarkable stability, maintaining BP nanosheet properties for over 24 hours in ambient conditions.
- Pt@BP exhibited effective interaction with DNA both in vitro and within cells.
- Significant enhancement in drug sensitivity was observed in cisplatin-resistant cancer cell lines treated with Pt@BP compared to cisplatin alone.
- Pt@BP showed a good cellular uptake rate.
Conclusions:
- The study successfully stabilized bare black phosphorus (BP) using cationic cisplatin species, creating a novel Pt@BP material.
- Pt@BP shows promise as a platform for synergistic photothermal and chemotherapy, particularly for treating cisplatin-resistant cancers.
- This work opens new avenues for utilizing BP-based nanomaterials in clinical applications.
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