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Serological screening for celiac disease in children with systemic lupus erythematosus

Yasin Şahin1, Sezgin Şahin2, Amra Adrovic2

  • 1Department of Pediatric Gastroenterology, İstanbul University-Cerrahpaşa School of Medicine, İstanbul, Turkey.

European Journal of Rheumatology
|May 10, 2019
PubMed

Insights

This study found no cases of celiac disease (CD) in children with juvenile systemic lupus erythematosus (JSLE). Further research with larger patient cohorts is recommended to confirm this finding regarding the association between JSLE and CD.

Area of Science:

  • Pediatric Rheumatology
  • Gastroenterology
  • Autoimmune Diseases

Background:

  • Juvenile Systemic Lupus Erythematosus (JSLE) is a chronic autoimmune condition affecting multiple organ systems in children.
  • Celiac Disease (CD) is an autoimmune disorder triggered by gluten ingestion, primarily affecting the small intestine.
  • The potential co-occurrence of JSLE and CD warrants investigation due to shared autoimmune mechanisms.

Purpose of the Study:

  • To determine the prevalence of celiac disease (CD) in pediatric patients diagnosed with juvenile systemic lupus erythematosus (JSLE).
  • To explore any potential association between the presence of JSLE and the development of CD.

Main Methods:

  • A cross-sectional study involving 50 patients with JSLE was conducted between October 2015 and October 2017.
  • Serum levels of total IgA and tissue transglutaminase (tTG) IgA antibodies were measured.
  • Patients with elevated tTG IgA underwent further testing for anti-endomysial antibodies (EMAs), followed by gastroduodenoscopy and intestinal biopsy if EMA positive.

Main Results:

  • The study cohort comprised 44 females (88.0%) and 6 males (12.0%).
  • Of the 50 JSLE patients, 3 (6.0%) tested positive for tTG IgA antibodies.
  • None of the patients with positive tTG IgA results had positive EMA IgA antibodies, and no CD diagnosis was confirmed.

Conclusions:

  • This study did not identify any cases of celiac disease in the evaluated cohort of children with juvenile systemic lupus erythematosus.
  • Larger-scale studies involving more patients with JSLE are necessary to establish a more definitive conclusion regarding the absence of CD in this population.
Abstract

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