Related Experiment Video
Updated: Jan 25, 2026

Activating Autophagy by Aerobic Exercise in Mice
Published on: February 3, 2017
Isarubrolones Containing a Pyridooxazinium Unit from Streptomyces as Autophagy Activators
Linli Li1, Shufen Li1, Bingya Jiang1
1NHC Key Laboratory of Biotechnology of Antibiotics, Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , People's Republic of China.
Abstract:
Isarubrolones are bioactive polycyclic tropoloalkaloids from Streptomyces. Three new isarubrolones (2-4), together with the known isarubrolone C (1) and isatropolones A (5) and C (6, 3( R)-hydroxyisatropolone A), were identified from Streptomyces sp. CPCC 204095. The structures of these compounds were determined using a combination of mass spectrometry, 1D and 2D NMR spectroscopy, and ECD. Compounds 3 and 4 feature a pyridooxazinium unit, which is rarely seen in natural products. Compound 6 could conjugate with amino acids or amines to expand the structural diversity of isarubrolones with a pentacyclic or hexacyclic core. Importantly, 1 and 3-6 were found to induce complete autophagy.
Related Concept Videos
Autophagy
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
Measurement: Standard Units
Measurement: Derived Units
Motor Units
Motor Units
Motor units come in different sizes, with smaller units...
Units of Measurement
There are various well-known historical measurement systems, such as the Babylonian system, the Roman system, the Egyptian system, the Olympian system, the British system, and the Indus...

