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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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The In ovo CAM-assay as a Xenograft Model for Sarcoma

The In ovo CAM-assay as a Xenograft Model for Sarcoma

Published on: July 17, 2013

Histiocytic Sarcoma.

Yin P Hung¹, Xiaohua Qian¹

¹From the Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts (Dr Hung); and Fine Needle Aspiration Service, Brigham and Women's Hospital, Boston, Massachusetts, the Department of Pathology, Harvard Medical School, Boston, Massacusetts, and Bone and Soft Tissue Pathology Service, Dana Farber Cancer Institute, Boston, Massachusetts (Dr Qian).

Archives of Pathology & Laboratory Medicine

|May 10, 2019

Summary

This summary is machine-generated.

Histiocytic sarcoma is a rare cancer of histiocytes with a poor prognosis, often presenting outside lymph nodes. Molecular studies reveal potential therapeutic targets in its pathogenesis.

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Last Updated: Jan 25, 2026

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Area of Science:

Oncology
Pathology
Genetics

Background:

Histiocytic sarcoma is a rare malignant neoplasm of histiocytes.
It typically presents extranodally and has a poor clinical outcome, especially in disseminated cases.
A history of hematolymphoid disorders suggests potential transdifferentiation in its pathogenesis.

Purpose of the Study:

To review the diagnostic challenges of histiocytic sarcoma.
To highlight the importance of morphologic and immunohistochemical analysis.
To discuss recent molecular findings and potential therapeutic targets.

Main Methods:

Review of morphologic and immunophenotypic features.
Application of immunohistochemical markers for diagnosis.
Analysis of targeted next-generation sequencing data.

Main Results:

Histiocytic sarcoma diagnosis is challenging due to rarity and overlap with mimics.
Immunohistochemistry is crucial for confirming histiocytic lineage and excluding differential diagnoses.
Recurrent alterations in the MAP kinase pathway and chromatin regulators were identified.

Conclusions:

Accurate diagnosis requires careful morphologic assessment and specific immunohistochemistry.
Molecular alterations in MAP kinase pathway and chromatin regulators offer potential therapeutic avenues.
Further research into histiocytic sarcoma pathogenesis may lead to novel treatment strategies.