Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intravitreal trifluorothymidine and retinal toxicity.

M P Pang, G A Peyman, J Nikoleit

    Retina (Philadelphia, Pa.)
    |January 1, 1986
    PubMed
    Summary

    Intraocular trifluorothymidine was found to be non-toxic in albino rabbits when administered via intravitreal injection or during pars plana vitrectomy. This study assessed its safety for potential ophthalmic applications.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Modulation of sensitivity to hyperbaric oxygen by CO2 in newborn rats.

    Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc·1995
    Same author

    Study of lymphocyte dynamics in the ocular circulation: technique of labeling cells.

    Current eye research·1995
    Same author

    A practical guideline for management of endophthalmitis.

    Ophthalmic surgery·1995
    Same author

    Direction and location of retinotomy for removal of subretinal neovascular membranes.

    Ophthalmic surgery·1995
    Same author

    Posterior segment triple surgery after traumatic eye injuries.

    Ophthalmic surgery·1995
    Same author

    Choroidal hyperpermeability in central serous choroidopathy: a new concept?

    Archives of ophthalmology (Chicago, Ill. : 1960)·1995

    Area of Science:

    • Ophthalmology
    • Toxicology
    • Retinal Science

    Background:

    • Trifluorothymidine is an antiviral agent.
    • Its intraocular safety profile requires evaluation for ophthalmic use.

    Purpose of the Study:

    • To determine the toxicity of trifluorothymidine when administered intraocularly in albino rabbits.
    • To assess safety via intravitreal injection and during pars plana vitrectomy.

    Main Methods:

    • Albino rabbits received intravitreal injections or trifluorothymidine in vitrectomy infusion solutions.
    • Ophthalmic evaluations included indirect ophthalmoscopy, electroretinography, and histology.

    Main Results:

    • An intravitreal injection of 200 micrograms/0.1 ml trifluorothymidine was non-toxic.

    Related Experiment Videos

  • A vitrectomy solution with 60 micrograms/ml trifluorothymidine was also found to be non-toxic.

    • Conclusions:

    • Intraocular administration of trifluorothymidine, via intravitreal injection or during vitrectomy, is safe in the rabbit eye model.
    • These findings support further investigation of trifluorothymidine for ophthalmic indications.