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Related Experiment Video

Updated: Jan 25, 2026

Visualization of Motor Axon Navigation and Quantification of Axon Arborization In Mouse Embryos Using Light Sheet Fluorescence Microscopy
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Visualization of Motor Axon Navigation and Quantification of Axon Arborization In Mouse Embryos Using Light Sheet Fluorescence Microscopy

Published on: May 11, 2018

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Axons Navigate Noise with 190RhoGAP.

Pavol Zelina1, R Jeroen Pasterkamp1

  • 1Department of Translational Neuroscience, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht 3584 CG, the Netherlands.

Neuron
|May 10, 2019
PubMed
Summary

Motor axons navigate the embryonic spinal cord by ignoring incorrect guidance cues. The protein p190RhoGAP binds to DCC, preventing unwanted reactions to Netrin-1 signals.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Biology

Background:

  • Axon guidance is crucial for neural circuit formation.
  • Netrin-1 is a key guidance cue, but its precise regulation is not fully understood.
  • Motor axons must navigate complex environments during embryonic development.

Purpose of the Study:

  • To investigate the mechanisms by which navigating axons ignore irrelevant guidance signals.
  • To understand how motor axons exit the embryonic spinal cord.

Main Methods:

  • The study utilized molecular and genetic techniques in an embryonic model system.
  • Investigated the interaction between p190RhoGAP and DCC.
  • Assessed the role of this interaction in response to Netrin-1 signaling.

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Morphological and Functional Evaluation of Axons and their Synapses during Axon Death in Drosophila melanogaster
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Morphological and Functional Evaluation of Axons and their Synapses during Axon Death in Drosophila melanogaster

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Related Experiment Videos

Last Updated: Jan 25, 2026

Visualization of Motor Axon Navigation and Quantification of Axon Arborization In Mouse Embryos Using Light Sheet Fluorescence Microscopy
08:56

Visualization of Motor Axon Navigation and Quantification of Axon Arborization In Mouse Embryos Using Light Sheet Fluorescence Microscopy

Published on: May 11, 2018

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In Situ Visualization of Axon Growth and Growth Cone Dynamics in Acute Ex Vivo Embryonic Brain Slice Cultures
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In Situ Visualization of Axon Growth and Growth Cone Dynamics in Acute Ex Vivo Embryonic Brain Slice Cultures

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Morphological and Functional Evaluation of Axons and their Synapses during Axon Death in Drosophila melanogaster
10:29

Morphological and Functional Evaluation of Axons and their Synapses during Axon Death in Drosophila melanogaster

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Main Results:

  • Demonstrated that the binding of p190RhoGAP to DCC is essential for suppressing inappropriate responses to Netrin-1.
  • Showed that this suppression allows motor axons to successfully exit the embryonic spinal cord.
  • Identified a critical regulatory mechanism for axon pathfinding.

Conclusions:

  • p190RhoGAP acts as a crucial regulator of axon guidance by interacting with DCC.
  • This interaction prevents motor axons from misinterpreting Netrin-1 signals, ensuring proper spinal cord exit.
  • The findings provide new insights into the molecular control of neural development.