Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clinically significant danazol-carbamazepine interaction.

J J Zielinski, E M Lichten, D Haidukewych

    Therapeutic Drug Monitoring
    |January 1, 1987
    PubMed
    Summary

    Danazol therapy significantly increases carbamazepine serum levels in epilepsy patients, potentially causing toxicity. Close monitoring of carbamazepine is crucial when used with danazol.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Individual patient data meta-analysis of randomized evidence to assess the effectiveness of laparoscopic uterosacral nerve ablation in chronic pelvic pain.

    Human reproduction update·2010
    Same author

    Meta-analysis using individual patient data from randomised trials to assess the effectiveness of laparoscopic uterosacral nerve ablation in the treatment of chronic pelvic pain: a proposed protocol.

    BJOG : an international journal of obstetrics and gynaecology·2007
    Same author

    Doing unto others? Emergency medicine residents' willingness to be treated by moonlighting residents and nonphysician clinicians in the emergency department.

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine·2001
    Same author

    Dehydroepiandrosterone and exercise in golden hamsters.

    Physiology & behavior·1999
    Same author

    Preconception care in diabetic women.

    The Journal of reproductive medicine·1999
    Same author

    The confirmation of a biochemical marker for women's hormonal migraine: the depo-estradiol challenge test.

    Headache·1996

    Area of Science:

    • Pharmacology
    • Clinical Pharmacy
    • Neurology

    Background:

    • Epilepsy management often involves antiepileptic drugs like carbamazepine.
    • Fibrocystic breast disease is treated with danazol, a synthetic androgen.
    • Potential drug-drug interactions require careful consideration in patients with comorbidities.

    Purpose of the Study:

    • To investigate the pharmacokinetic interaction between carbamazepine and danazol.
    • To assess the impact of danazol on serum concentrations of antiepileptic drugs.
    • To evaluate the clinical significance of concurrent carbamazepine and danazol administration.

    Main Methods:

    • Serum concentrations of antiepileptic drugs were measured in six epilepsy patients.
    • Measurements were taken before, during, and after danazol therapy.
    • Carbamazepine serum levels were specifically analyzed for changes.

    Main Results:

    • Carbamazepine serum levels nearly doubled during danazol therapy.
    • A significant drug-drug interaction between carbamazepine and danazol was observed.
    • The findings suggest a potential for acute carbamazepine toxicity.

    Conclusions:

    • Concurrent use of carbamazepine and danazol necessitates awareness of a significant drug interaction.
    • Monitoring carbamazepine serum levels is essential for patient safety during combined therapy.
    • This interaction poses a clinically relevant risk requiring vigilant patient management.

    Related Experiment Videos