Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insomnia01:27

Insomnia

426
Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
426
Management of Insomnia01:19

Management of Insomnia

564
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
564
Long-term Depression01:05

Long-term Depression

33.2K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.2K
Long-term Depression01:03

Long-term Depression

3.1K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.1K
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

858
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
858
Freezing Point Depression and Boiling Point Elevation03:12

Freezing Point Depression and Boiling Point Elevation

39.7K
Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
39.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oral contraceptive usage among healthcare workers and its impact on COVID-19 booster vaccination immunogenicity.

NPJ vaccines·2026
Same author

Risks Associated With Benzodiazepine Long-Term Use in Chronic Insomnia: A Systematic Review and (Network) Meta-Analysis.

Journal of sleep research·2026
Same author

Association Between Sleep Quality and Oxidative Stress in Postoperative Cardiovascular Patients-A Pilot Study.

Journal of sleep research·2026
Same author

HCA2 Receptors in Lymphocytes and Keratinocytes Affect Murine Contact Allergic Inflammation.

Experimental dermatology·2026
Same author

Insomnia disorder.

Nature reviews. Disease primers·2026
Same author

Cortical firing dynamics during micro-arousals vary with sleep/wake history and micro-arousal duration.

Scientific reports·2026

Related Experiment Video

Updated: Jan 25, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.3K

Sleep, insomnia, and depression.

Dieter Riemann1, Lukas B Krone2,3, Katharina Wulff4,5

  • 1Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. dieter.riemann@uniklinik-freiburg.de.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|May 10, 2019
PubMed
Summary

Sleep disturbances, including insomnia, are closely linked to depression. Research explores how treating sleep issues might prevent depression and improve therapeutic outcomes.

More Related Videos

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.6K
Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia
04:59

Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia

Published on: May 30, 2025

1.4K

Related Experiment Videos

Last Updated: Jan 25, 2026

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

1.3K
Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.6K
Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia
04:59

Heat-sensitive Moxibustion as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Insomnia

Published on: May 30, 2025

1.4K

Area of Science:

  • Psychiatry
  • Neuroscience
  • Sleep Medicine

Background:

  • Co-occurrence of melancholia and sleep disturbances is long-established.
  • Polysomnography reveals sleep continuity disruption in depression, including decreased Slow Wave Sleep and disinhibited REM sleep.
  • REM sleep abnormalities were not effective differential-diagnostic markers for depression subtypes.

Purpose of the Study:

  • To link sleep regulatory mechanisms with physiological changes in depression.
  • To explore the role of insomnia as a transdiagnostic symptom.
  • To investigate if early insomnia treatment can prevent depression.

Main Methods:

  • Review of existing research on sleep disturbances and depression.
  • Analysis of polysomnography findings in depressed patients.
  • Discussion of chrono-medical strategies like sleep deprivation and light therapy.
  • Exploration of the Cholinergic REM Induction Test.

Main Results:

  • Antidepressant agents suppress REM sleep, with a dose-response relationship to therapeutic effects.
  • Insomnia is increasingly viewed as a transdiagnostic symptom, particularly related to depression.
  • Research into insomnia as a phenotype offers new avenues for understanding mechanisms and clinical practice.

Conclusions:

  • Understanding sleep regulatory mechanisms is crucial for depression research and treatment.
  • Early and adequate treatment of insomnia may hold potential for depression prevention.
  • Future strategies should focus on the interplay between sleep and depression therapeutics.