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Updated: Jan 25, 2026

Preparation and Use of HIV-1 Infected Primary CD4+ T-Cells as Target Cells in Natural Killer Cell Cytotoxic Assays
Published on: March 14, 2011
Hopf bifurcation of an age-structured HIV infection model with logistic target-cell growth
Zhong-Kai Guo1,2, Hai-Feng Huo1,3, Hong Xiang3
1a College of Electrical and Information Engineering , Lanzhou University of Technology , Lanzhou , People's Republic of China.
Abstract:
In this paper, we investigate an age-structured HIV infection model with logistic growth for target cell. We rewrite the model as an abstract non-densely defined Cauchy problem and obtain the condition which guarantees the existence of the unique positive steady state. By linearizing the model at steady state and analysing the associated characteristic transcendental equations, we study the local asymptotic stability of the steady state. Furthermore, by using Hopf bifurcation theorem in Liu et al., we show that Hopf bifurcation occurs at the positive steady state when bifurcating parameter crosses some critical values. Finally, we perform some numerical simulations to illustrate our results.
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