Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

858
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
858
Functions of Connective Tissues01:17

Functions of Connective Tissues

14.9K
Connective tissues perform a broad range of functions in the body. Their primary function is to connect and link different tissues in the body and act as packaging material between tissues. The areolar tissue, a connective tissue prototype, commonly cements various tissue types in diverse body organs. In contrast, adipose tissue cushions internal organs while insulating the body from heat loss.
Hard connective tissues, such as bones and cartilage, provide structure and support to the body.
14.9K
Stages of Sleep01:22

Stages of Sleep

1.4K
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
1.4K
Understanding Sleep01:11

Understanding Sleep

1.4K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.4K
Sleep Apnea01:21

Sleep Apnea

514
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
514
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

6.9K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
6.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trends and Outcomes of Sentinel Lymph Node Biopsy in Early-stage Vulvar Squamous Cell Carcinoma: A Population-based Study.

Journal of Cancer·2018
Same author

[Comparison and Discussion of National/Military Standards Related to Flow Measurement of Medical Injection Pump].

Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation·2018
Same author

Multiplexed Targeting of Barrett's Neoplasia with a Heterobivalent Ligand: Imaging Study on Mouse Xenograft in Vivo and Human Specimens ex Vivo.

Journal of medicinal chemistry·2018
Same author

Lymph node ratio has prognostic value related to the number of positive lymph nodes in patients with vulvar cancer.

Future oncology (London, England)·2018
Same author

lncRNAs are novel biomarkers for differentiating between cisplatin-resistant and cisplatin-sensitive ovarian cancer.

Oncology letters·2018
Same author

Widowed status increases the risk of death in vulvar cancer.

Future oncology (London, England)·2018

Related Experiment Video

Updated: Jan 25, 2026

Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

2.4K

Functional connectivity and the sleep-deprived brain.

Michael W L Chee1, Juan Zhou2

  • 1Centre for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke-NUS Medical School, Singapore, Singapore.

Progress in Brain Research
|May 11, 2019
PubMed
Summary
This summary is machine-generated.

Sleep deprivation alters resting-state functional connectivity (rsFC) by disrupting brain network integration and segregation. Vigilance changes impact rsFC, highlighting the need to prevent sleep in fMRI studies.

Keywords:
Functional connectivityGlobal signalNetwork integration and segregationSleep deprivation

More Related Videos

The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila
06:06

The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila

Published on: December 14, 2020

4.2K
Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
03:46

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Published on: October 11, 2018

11.0K

Related Experiment Videos

Last Updated: Jan 25, 2026

Establishing a Device for Sleep Deprivation in Mice
05:05

Establishing a Device for Sleep Deprivation in Mice

Published on: September 22, 2023

2.4K
The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila
06:06

The Sleep Nullifying Apparatus: A Highly Efficient Method of Sleep Depriving Drosophila

Published on: December 14, 2020

4.2K
Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling
03:46

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Published on: October 11, 2018

11.0K

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Resting-state functional connectivity (rsFC) measures brain activity during rest using BOLD signals.
  • Sleep deprivation is known to affect cognitive functions and brain activity.
  • Maintaining vigilance during functional magnetic resonance imaging (fMRI) scans is crucial for reliable data.

Purpose of the Study:

  • To investigate the effects of sleep deprivation on rsFC patterns.
  • To understand how vigilance changes influence rsFC.
  • To identify predictors of vigilance decline during sleep deprivation.

Main Methods:

  • Analysis of resting-state functional connectivity (rsFC) using BOLD signals.
  • Assessment of changes in network integration and segregation.
  • Evaluation of global signal amplitude.
  • Dynamic functional connectivity analysis to assess arousal states.

Main Results:

  • Sleep deprivation induced three major changes in rsFC: loss of within-network and between-network integration, loss of between-network segregation, and increased global signal.
  • Vigilance levels significantly affect rsFC.
  • Dynamic functional connectivity during a well-rested state can predict susceptibility to vigilance decline when sleep-deprived.

Conclusions:

  • Sleep deprivation profoundly alters brain functional connectivity, impacting network organization.
  • Vigilance is a critical factor influencing rsFC, with implications for neuropsychiatric research.
  • Dynamic functional connectivity measures may offer insights into individual differences in vulnerability to sleep loss.