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Updated: Jan 25, 2026

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis
Published on: October 13, 2016
Therapeutic non-invasive brain stimulation in amyotrophic lateral sclerosis: rationale, methods and experience
Evan C Edmond1,2,3,4, Charlotte J Stagg1,2,3,4, Martin R Turner5,2,3,4
1Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.
Abstract:
The neurodegenerative syndrome amyotrophic lateral sclerosis (ALS) is characterised by increased cortical excitability, thought to reflect pathological changes in the balance of local excitatory and inhibitory neuronal influences. Non-invasive brain stimulation (NIBS) has been shown to modulate cortical activity, with some protocols showing effects that outlast the stimulation by months. NIBS has been suggested as a potential therapeutic approach for disorders associated with changes in cortical neurophysiology, including ALS. This article reviews NIBS methodology, rationale for its application to ALS and progress to date.
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