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Phage-Based Artificial Niche: The Recent Progress and Future Opportunities in Stem Cell Therapy
Kshitiz Raj Shrestha1, So Young Yoo1,2
1BIO-IT Foundry Technology Institute, Pusan National University, Busan 46241, Republic of Korea.
Artificial stem cell niches, including engineered phage, can control stem cell behavior for regenerative medicine. These niches mimic natural environments to guide stem cell self-renewal and differentiation for disease treatment.
Area of Science:
- Biomedical Engineering
- Stem Cell Biology
- Regenerative Medicine
Background:
- Stem cell self-renewal and differentiation are vital for regenerative medicine.
- The stem cell niche microenvironment is crucial for stem cell function both in vivo and in vitro.
- Niches provide essential chemical, physical, and topological cues to stem cells.
Purpose of the Study:
- To review artificial niche technologies for stem cell manipulation.
- To explore engineered phage as a component of artificial stem cell niches.
- To discuss the therapeutic potential of phage-based artificial niches in tissue repair and regeneration.
Main Methods:
- Literature review of artificial stem cell niches.
- Analysis of engineered phage applications in biomaterials.
- Discussion of stem cell-niche interactions.
Main Results:
- Artificial niches can recapitulate or manipulate stem cell behavior.
- Engineered phage offer a novel approach to artificial niche construction.
- Phage-based niches show promise for regenerative therapies.
Conclusions:
- Artificial niches are key to harnessing stem cell potential.
- Engineered phage represent a versatile tool for creating advanced stem cell niches.
- Phage-based artificial niches hold significant therapeutic promise for tissue regeneration.
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