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Updated: Jan 25, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Peripheral follicular helper T cells in acute viral diseases: a perspective on dengue
Luis A Sánchez-Vargas1, Anuja Mathew1
1Department of Cell & Molecular Biology, Institute for Immunology & Informatics, University of Rhode Island, Providence, RI 02903, USA.
Abstract:
Follicular helper T cells (TFH) are a predominant subset of CD4+ T cells specialized in providing help to B cells in germinal centers and necessary to generate T cell-dependent antibody responses. Peripheral TFH (pTFH) are the counterpart of TFH found in the circulation, which resemble TFH in many aspects of their phenotype and function. The CD4+ pTFH subset has received a lot of interest recently because they are easy to access and have the potential to serve as a biomarker for long-lasting humoral immunity. This review will discuss recent findings of pTFH in human acute viral diseases with a focus on dengue infection.
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