TAS2R38 bitter taste genotype is associated with complementary feeding behavior in infants

Area of Science:

• Genetics
• Human Nutrition
• Pediatrics

Background:

• Genetically influenced bitter taste perception is linked to food preferences and eating behaviors in children and adults.
• The TAS2R38 gene specifically mediates bitter taste sensitivity.
• Understanding genetic influences on early eating behaviors is crucial for addressing potential feeding issues.

Purpose of the Study:

• To investigate the association between TAS2R38 bitter taste genotype and the acceptance of first complementary foods in infants.
• To determine if genetic bitter taste sensitivity plays a role in infant feeding behavior during the introduction of solid foods.

Main Methods:

• Infants' TAS2R38 genotypes were determined at birth, classifying them as bitter-insensitive (AVI/AVI) or bitter-sensitive (AVI/PAV or PAV/PAV).
• Parents recorded infant acceptance of a first complementary meal (150 mL) between 4 to 6 months of age.
• Data on food composition, breastfeeding, feeding practices, and infant growth were collected.

Main Results:

• Of 131 infants, 34.3% were bitter-insensitive and 65.6% were bitter-sensitive.
• Bitter-insensitive infants were significantly more likely to consume the entire first complementary meal (31%) compared to bitter-sensitive infants (13%) (p=0.006).
• This association remained significant after accounting for sex, breastfeeding, and food type; infant growth at 6 months did not differ between groups.

Conclusions:

• Variations in the TAS2R38 bitter taste gene are associated with the acceptance of initial complementary foods in infants.
• These findings suggest a potential role for genetic bitter taste sensitivity in shaping eating behaviors during the critical weaning period.
• Early identification of genetic predispositions may inform strategies for promoting healthy infant feeding practices.