Related Experiment Video
Updated: Jan 25, 2026

Grafting Multiwalled Carbon Nanotubes with Polystyrene to Enable Self-Assembly and Anisotropic Patchiness
Published on: April 1, 2018
Multiwalled Carbon Nanotubes for Combination Therapy: a Biodistribution and Efficacy Pilot Study
Giacomo Biagiotti1,2, Federica Pisaneschi2, Seth T Gammon2
1Department of Chemistry "Ugo Schiff", Università degli Studi di Firenze, via della Lastruccia 3-13, 50019 Sesto Fiorentino, Firenze, Italy.
Abstract:
A drug delivery system (DDS) for combined therapy, based on a short oxidized multiwalled carbon nanotube, is reported. It was prepared exploiting a synthetic approach which allowed loading of two drugs, doxorubicin and metformin, the targeting agent biotin and a radiolabeling tag, to enable labeling with Ga-68 or Cu-64 in order to perform an extensive biodistribution study by PET/CT. The DDS biodistribution profile changes with different administration methods. Once administered at therapeutic doses, the DDS showed a marginal beneficial effect on 4T1 tumor bearing mice, a syngeneic and orthotopic model of triple negative breast cancer, with survival extended by 1 week and 2 days in 20% of the mice. This is encouraging given the aggressiveness of the 4T1 tumor. Furthermore our DDS was well tolerated, ruling out concerns regarding the toxicity of carbon nanotubes.
Related Concept Videos
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Pilot and Numeric Relaying
The Carbon Cycle
Carbon Skeletons
Self-Efficacy
Carbonation Shrinkage
The concrete's permeability is slightly reduced as calcium carbonate produced during the reaction fills its pores. Furthermore, its strength is slightly enhanced as the water released during the reaction...

