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Updated: Jan 25, 2026

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Lactic Acidosis in Children - A Varied Presentation.

Ira Shah1

  • 1Department of Pediatrics, B J Wadia Hospital for Children, Mumbai, India.

Journal of Pediatric Intensive Care
|May 11, 2019
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Summary

Primary lactic acidemias are pyruvate metabolism disorders. While often presenting classically, these three cases highlight varied symptoms like hematemesis, unconsciousness, and seizures, emphasizing diverse clinical presentations.

Keywords:
childrenlactic acidosispresentation

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Area of Science:

  • Biochemistry
  • Genetics
  • Pediatric Medicine

Background:

  • Primary lactic acidemias stem from pyruvate metabolism defects or respiratory chain issues.
  • Other metabolic disorders can cause lactic acidosis but are distinguishable via specific diagnostic tests.

Observation:

  • Classical symptoms include growth retardation, ataxia, stroke, and elevated lactic acid.
  • Diverse presentations observed: recurrent hematemesis with hypoglycemia, recurrent unconsciousness, and infantile convulsions.

Findings:

  • Three pediatric cases illustrate varied clinical manifestations of primary lactic acidemia.
  • The study underscores that lactic acidemia can present atypically, deviating from classical growth and neurological symptoms.

Implications:

  • Highlights the importance of considering primary lactic acidemia in children with unexplained metabolic derangements.
  • Emphasizes the need for broad diagnostic approaches to identify diverse presentations of lactic acidemia.
  • Aids clinicians in recognizing less common symptoms, improving timely diagnosis and management of lactic acidemia.