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Updated: Jan 25, 2026

Acute Myocardial Infarction in Rats
Published on: February 16, 2011
Acute Myocardial Injury in Association with Metformin Toxicity
Ashish Garg1, Nataly Judith Sánchez-Solano1, Sudheer R Gorla1
1Division of Pediatric Cardiology, Department of Pediatrics, Jackson Memorial Hospital, University of Miami/Miller School of Medicine, Miami, Florida, United States.
Abstract:
Metformin is one of the most commonly used oral hypoglycemic agents in the treatment of type 2 diabetes mellitus. Toxicity related to accidental or intentional ingestion of metformin is well reported in the pediatric literature. We report a case of transient acute myocardial injury documented by biochemical and electrophysiological evidences in an adolescent male who presented with intentional ingestion of a large dose of metformin. To our knowledge, this is the first such case of documented reversible myocardial injury in relation to metformin toxicity to be reported in the pediatric literature.
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