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Updated: Jan 25, 2026

Author Spotlight: Advanced Integrated Model for Sepsis-Induced Myopathy and Single-Cell Metabolic Analysis
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Role of Damage-Associated Molecular Patterns and Uncontrolled Inflammation in Pediatric Sepsis-Induced Multiple Organ

Alicia M Alcamo1,2, Diana Pang3, Dalia A Bashir4,5

  • 1Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.

Journal of Pediatric Intensive Care
|May 11, 2019
PubMed

Insights

Multiple organ dysfunction syndrome (MODS) in sepsis, a severe condition, presents diverse phenotypes and significantly increases mortality risk. Understanding these phenotypes, like TAMOF and MAS/HLH, is crucial for improving sepsis outcomes.

Area of Science:

  • Critical Care Medicine
  • Immunology
  • Pathophysiology

Background:

  • Sepsis-induced multiple organ dysfunction syndrome (MODS) affects 17-73% of patients, elevating mortality by 60%.
  • Diverse MODS phenotypes exist, sharing a common pathway of immune stimulation by PAMPs and DAMPs, leading to sustained inflammation.

Purpose of the Study:

  • To detail specific MODS phenotypes, focusing on thrombocytopenia-associated multiple organ failure (TAMOF) and macrophage activation syndrome (MAS) with hemophagocytic lymphohistiocytosis (HLH).
  • To review the role of mitochondrial dysfunction in MODS pathogenesis.

Main Methods:

  • Phenotypic analysis of MODS in sepsis.
  • Review of immune response pathways (PAMPs, DAMPs).
  • Examination of mitochondrial dysfunction's contribution.

Main Results:

  • MODS incidence and mortality risk are substantial.
  • Distinct MODS phenotypes, including TAMOF and MAS/HLH, are characterized by specific inflammatory profiles.
  • Mitochondrial dysfunction is a key factor in MODS development.

Conclusions:

  • Understanding MODS phenotypes is critical for targeted interventions.
  • Immune dysregulation and mitochondrial dysfunction are central to MODS pathogenesis.
  • Further research into TAMOF, MAS/HLH, and mitochondrial roles may improve sepsis management.
Keywords:
danger-associated molecular patternshemophagocytic lymphohistiocytosismacrophage activation syndromemultiple organ dysfunction syndromepathogen-associated molecular patternspediatric severe sepsis

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