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Updated: Jan 25, 2026

Metabolic Profiling to Determine Bactericidal or Bacteriostatic Effects of New Natural Products using Isothermal Microcalorimetry
Published on: October 29, 2020
Recent advances of metabolic engineering strategies in natural isoprenoid production using cell factories
Meijie Li1, Feifei Hou1, Tong Wu1
1Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 135 Songling Road, Qingdao 266101, P. R. China. li_mj@qibebt.ac.cn Houff@qibebt.ac.cn wutong@qibebt.ac.cn lifl@qibebt.a.cn xianmo@qibebt.ac.cn zhanghb@qibebt.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, P. R. China.
Abstract:
Covering: up to 2019As abundant natural products, isoprenoids have many useful industrial applications in the manufacturing of drugs, fragrances, food additives, colorants, rubber and advanced biofuels. The microbial production of isoprenoids has received much attention in recent years. Metabolic engineering approaches and synthetic biology have been utilized to reconstruct and optimize the metabolic pathways for isoprenoid production in cell factories. In this review, the recent advances in isoprenoid production using microbes are summarized, with a focus on MEP and MVA pathway engineering, downstream isoprenoid pathway engineering and microbial host engineering, which mainly includes central carbon pathway engineering. Finally, future perspectives for the improvement of isoprenoid production are discussed.
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