Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Receptor-mediated Endocytosis01:39

Receptor-mediated Endocytosis

110.7K
Overview
110.7K
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

7.6K
Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
7.6K
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

11.7K
The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
11.7K
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

3.3K
3.3K
Carrier-Mediated Transport01:06

Carrier-Mediated Transport

1.2K
Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
1.2K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

83.6K
Overview
83.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prenatal Smoking Exposures and Epigenome-Wide Methylation in Newborn Blood.

Environmental health perspectives·2026
Same author

Commentary on: "The Effects of Sun Exposure and Pigmentation Phenotype on Prognosis in Metastatic Melanoma".

Acta dermato-venereologica·2026
Same author

Corrigendum to "Environmental exposure and cancer incidence in offshore petroleum workers in Norway" [Environ. Res. 264 (2025) 121407].

Environmental research·2026
Same author

Childhood internalising symptoms at ages 3 and 6: a meta-analysis of epigenome-wide associations from cord and peripheral blood.

Journal of child psychology and psychiatry, and allied disciplines·2026
Same author

The Low FODMAP Diet in Celiac Disease: 5-Year Follow-Up of a Randomized Controlled Trial.

Gastro hep advances·2026
Same author

Temporal trends in the probability of melanoma diagnosis in four Nordic countries, 1973-1999.

Cancer causes & control : CCC·2026

Related Experiment Video

Updated: Jan 25, 2026

Channelrhodopsin2 Mediated Stimulation of Synaptic Potentials at Drosophila Neuromuscular Junctions
09:12

Channelrhodopsin2 Mediated Stimulation of Synaptic Potentials at Drosophila Neuromuscular Junctions

Published on: March 16, 2009

14.1K

Global test for high-dimensional mediation: Testing groups of potential mediators.

Vera Djordjilović1, Christian M Page2,3, Jon Michael Gran1,2

  • 1Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, University of Oslo, Oslo, Norway.

Statistics in Medicine
|May 11, 2019
PubMed
Summary

We developed a new method to test if multiple variables mediate the relationship between an exposure and an outcome. Our approach, ScreenMin, effectively controls statistical errors in complex mediation analyses.

Keywords:
false discovery ratefamilywise error ratehigh-dimensional datamultiple mediators

More Related Videos

Monitoring Stub1-Mediated Pexophagy
08:26

Monitoring Stub1-Mediated Pexophagy

Published on: May 12, 2023

2.0K
Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures
08:02

Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures

Published on: July 27, 2022

2.9K

Related Experiment Videos

Last Updated: Jan 25, 2026

Channelrhodopsin2 Mediated Stimulation of Synaptic Potentials at Drosophila Neuromuscular Junctions
09:12

Channelrhodopsin2 Mediated Stimulation of Synaptic Potentials at Drosophila Neuromuscular Junctions

Published on: March 16, 2009

14.1K
Monitoring Stub1-Mediated Pexophagy
08:26

Monitoring Stub1-Mediated Pexophagy

Published on: May 12, 2023

2.0K
Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures
08:02

Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures

Published on: July 27, 2022

2.9K

Area of Science:

  • Biostatistics
  • Genetics
  • Epidemiology

Background:

  • Mediation analysis is crucial for understanding biological pathways.
  • Testing high-dimensional mediators presents statistical challenges.
  • Existing methods may lack power or control for multiple testing.

Purpose of the Study:

  • To develop a robust global test for high-dimensional mediation.
  • To introduce a multiple testing procedure (ScreenMin) for simultaneous mediator group testing.
  • To evaluate the performance of the proposed methods.

Main Methods:

  • A global mediation test combining a global test with the intersection-union principle.
  • The ScreenMin procedure for controlling familywise error rate or false discovery rate.
  • Simulation studies and application to a lung cancer cohort study.

Main Results:

  • The proposed global test performs comparably or better than existing methods.
  • ScreenMin provides asymptotic control of error rates in multiple mediator testing.
  • The approach was successfully applied to investigate smoking, lung cancer, and DNA methylation.

Conclusions:

  • The developed global test and ScreenMin procedure offer powerful tools for high-dimensional mediation analysis.
  • These methods advance our ability to uncover complex etiological pathways.
  • The findings have implications for understanding environmental exposures and disease risk.