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Updated: Jan 25, 2026

Synthesis and Characterization of Functionalized Metal-organic Frameworks
Published on: September 5, 2014
DNA-Functionalized Metal-Organic Framework: Cell Imaging, Targeting Drug Delivery and Photodynamic Therapy
Yuanchao Zhang1,2, Qingli Wang2, Guang Chen1
1School of Chemistry and Chemical Engineering , Qufu Normal University , Qufu 273165 , Shandong , P. R. China.
Abstract:
Here, DNA-functionalized nanoscale PCN-224 is established with the aptamer of A549 lung cancer cells. The aptamer was modified with carboxyl and fluorescein at the two terminals. When touching the A549 cells, DOX@PCN-224-DNA can trace tumor cells and present good targeting therapy by the combination of chemotherapy and photodynamic therapy. This facile aptamer functionalization of PCN-224 offers an opportunity to develop metal-organic framework-based target-directed therapy and biosensors.
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