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Butorphanol improves CO2 response and ventilation after fentanyl anesthesia
Anesthesia and Analgesia
|June 1, 1987
Summary
Butorphanol, a mixed agonist-antagonist narcotic, significantly improved ventilation and CO2 response in patients recovering from fentanyl anesthesia. This suggests butorphanol can be a valuable tool for managing respiratory function post-surgery.
Area of Science:
- Anesthesiology
- Pharmacology
Background:
- Fentanyl anesthesia can suppress respiratory drive.
- Postoperative respiratory depression is a significant clinical concern.
Purpose of the Study:
- To evaluate the effect of butorphanol on CO2 response and ventilation in patients receiving fentanyl anesthesia.
- To establish a tentative dosage range for butorphanol in this context.
Main Methods:
- Twenty-two patients received isoflurane, nitrous oxide, and continuous fentanyl infusion.
- Postoperatively, three 1-mg intravenous doses of butorphanol were administered.
- Ventilatory parameters, CO2 response, vital signs, and plasma catecholamines were monitored.
Main Results:
- Butorphanol significantly increased respiratory rate, tidal volume, and minute ventilation.
- The slope of the ventilatory response to CO2 increased significantly post-butorphanol administration.
- No significant changes were observed in blood pressure, heart rate, pain intensity, or plasma epinephrine/norepinephrine levels.
Conclusions:
- Butorphanol effectively improves ventilation and CO2 responsiveness following fentanyl anesthesia.
- The primary respiratory benefits were observed after the initial dose of butorphanol.
- Butorphanol appears to be a safe option for managing postoperative respiratory function without significantly impacting hemodynamic stability or pain.