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Clinical experience with a transdermal nitroglycerin system.

R K Mahapatra, D Mahapatra, S Yaden

    Angiology
    |April 1, 1987
    PubMed
    Summary
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    Transdermal nitroglycerin patches effectively reduced angina frequency and consumption of sublingual nitroglycerin in patients with chronic stable angina pectoris. This treatment was well-tolerated with acceptable side effects.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Chronic stable angina pectoris significantly impacts patient quality of life.
    • Nitroglycerin is a cornerstone therapy for angina, but its delivery methods are continuously evolving.

    Purpose of the Study:

    • To evaluate the clinical efficacy, safety, and patient acceptance of a transdermal therapeutic system of nitroglycerin.
    • To assess the impact of individually titrated nitroglycerin patches on angina symptoms and medication use.

    Main Methods:

    • An open-label study involving 47 patients with chronic stable angina pectoris.
    • A thirteen-week treatment period including a two-week run-in and an eleven-week active drug phase.
    • Acute dose titration of nitroglycerin patches based on weekly patient diaries detailing angina frequency and sublingual nitroglycerin consumption.

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    Main Results:

    • Statistically significant reductions (p < 0.05) in angina frequency and sublingual nitroglycerin consumption were observed.
    • Common adverse reactions included headache (32 patients), skin rash (18), dizziness (10), palpitation and itching (9 each), nausea (7), flushing (3), and vomiting (1).
    • Side effects were generally tolerable, indicating good patient acceptance.

    Conclusions:

    • Individual dose titration of transdermal nitroglycerin is crucial for achieving significant antianginal effects.
    • The transdermal therapeutic system for nitroglycerin is convenient, well-tolerated, and demonstrates acceptable side effects in the studied population.