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The association between IL-17A and IL-23R polymorphisms and coronary artery disease risk in a Middle Eastern Chinese

Qiang Zhao1,2, Huaxin Jiang3, Teng Ma2

  • 1Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

Journal of Clinical Laboratory Analysis
|May 11, 2019
PubMed

Insights

Genetic variations in IL-17A and IL-23R are linked to coronary artery disease (CAD) risk. This study found specific polymorphisms in IL-17A (rs2275913) and IL-23R (rs6682925) associated with increased CAD susceptibility.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Immunology

Background:

  • Interleukin-17A (IL-17A) and Interleukin-23 Receptor (IL-23R) gene polymorphisms may influence gene expression and susceptibility to coronary artery disease (CAD).
  • Previous research on the association between IL-17A/IL-23R polymorphisms and CAD risk has yielded inconclusive results.

Purpose of the Study:

  • To investigate the association between specific polymorphisms in the IL-17A and IL-23R genes and the risk of developing coronary artery disease (CAD).

Main Methods:

  • A hospital-based case-control study involving 191 CAD patients and 131 controls.
  • Genotyping of IL-17A rs2275913 and IL-23R rs6682925 polymorphisms was performed using the Sequenom MassARRAY platform.
  • Patient and control groups were assessed using SXscore, and biochemical parameters like FPG, HbA1C, HDL, ApoA1, and Lp(a) were analyzed.

Main Results:

  • Patients with CAD exhibited higher FPG and HbA1C levels, and lower HDL and ApoA1 levels compared to controls. Lp(a) levels were significantly lower in controls than in cases.
  • The IL-17A rs2275913 (AA vs GG: OR=2.16; AG/AA vs GG: OR=1.81) and IL-23R rs6682925 (CC vs TT: OR=1.91) polymorphisms were associated with an increased risk of CAD.
  • Subgroup analysis indicated that the IL-23R rs6682925 polymorphism was significantly associated with increased CAD risk in patients with a high SXscore (CT/CC vs TT: OR=3.72).

Conclusions:

  • Type 2 Diabetes Mellitus (T2DM), elevated Lp(a), and reduced HDL-c and ApoA1 are identified as risk factors for CAD.
  • The IL-17A rs2275913 and IL-23R rs6682925 polymorphisms may play a role in the susceptibility to developing coronary artery disease.
Abstract

Keywords:
IL-17AIL-23RCADpolymorphismsusceptibility

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