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Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
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The Aging Thyroid: A Reappraisal Within the Geroscience Integrated Perspective
Claudio Franceschi1, Rita Ostan2, Stefano Mariotti3
1Department of Applied Mathematics, Institute of Information Technology, Mathematics, and Mechanics, Lobachevsky State University of Nizhny Novgorod-National Research University, Nizhny Novgorod, Russia.
Endocrine Reviews
|May 11, 2019
Summary
Thyroid aging is linked to common diseases and organ changes. This review explores aging mechanisms like inflammation and metabolism in the thyroid, highlighting research gaps and adaptive longevity strategies.
Area of Science:
- Gerontology and endocrinology
- Molecular mechanisms of aging
- Thyroid physiology
Background:
- Thyroid function is vital for metabolism, thermogenesis, and immunity.
- Thyroid aging contributes to age-related diseases and systemic changes.
- Geroscience provides a framework to understand thyroid aging.
Purpose of the Study:
- To review the role of aging mechanisms (geroscience pillars) in thyroid aging.
- To identify research gaps in thyroid aging.
- To explore thyroid function in centenarians as a model of healthy aging.
Main Methods:
- Review of existing literature on thyroid aging and geroscience pillars.
- Focus on inflammation, cellular senescence, gut dysbiosis, telomere shortening, proteostasis, stem cells, metabolism, and epigenetics.
- Analysis of thyroid function in centenarians.
Main Results:
- Alterations in aging pillars are present in the thyroid but understudied.
- Key areas include inflammation, macromolecular damage, proteostasis, stem cells, metabolism, and epigenetics.
- Thyroid function in centenarians suggests adaptive mechanisms for longevity.
Conclusions:
- Thyroid aging research is nascent and requires more attention.
- The concept of "thyroid biography" integrates lifelong factors affecting thyroid health.
- Understanding thyroid aging is crucial for addressing age-related diseases and promoting healthy longevity.
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