Related Experiment Video
Updated: Jan 25, 2026

Biomolecular Imaging of Cellular Uptake of Nanoparticles using Multimodal Nonlinear Optical Microscopy
Published on: May 16, 2022
Biological nascent evolution of snail bone and collagen revealed by nonlinear optical microscopy
Abstract:
Using nonlinear optical microscopy of coherent antistokes Raman scattering (CARS), second harmonic generation (SHG) and two-photo excitation fluorescence, we in situ observed how the collagen and the bone grow synergistically and competitively during nascent biological evolution. The and ions were first observed to be dispersed in the liquid environment, and the collagen was observed 2 days later. With the help of the collagen, the and ions gradually moved closer to the collagen, and then the bone was produced in the forms of CaCO3 and CaPO3 . When the bone was completed with the help of the collagen, the collagen gradually disappeared. The biological evolution of snail bone and collagen can be well revealed by CARS and SHG, and in addition, the biological evolution of structure and morphology can be clearly observed day by day.
Related Concept Videos
Imaging Biological Samples with Optical Microscopy
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
The Evidence for Evolution
Convergent Evolution
Nonlinear Pharmacokinetics: Causes of Nonlinearity
Nonlinear drug absorption can occur when the process is rate-limited by solubility, carrier-mediated transport systems, or saturation of the presystemic gut wall or hepatic metabolism. For instance, high doses of riboflavin...
Eukaryotic Evolution
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
Synteny and Evolution
Around 80 million years ago, the human and mice lineages diverged from the common ancestor. During the course of evolution, the ancestral...

