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Updated: Jan 25, 2026

Impression Cytology of the Lid Wiper Area
Published on: August 9, 2016
Papillary meningioma: Diagnosis by intraoperative crush smear cytology
Shilpa P Tathe1, Sanjay N Parate1
1Department of Pathology, Superspeciality Hospital and Government Medical College, Nagpur, Maharashtra, India.
Abstract:
Papillary meningioma is a rare, aggressive variant of meningioma. It accounts for less than 1% of all meningiomas. It is categorized as WHO grade III due to high rate of recurrence and metastasis. Histopathologic features of papillary meningioma are well described, but cytomorphology is rarely been described. We report a case of papillary meningioma, diagnosed on intraoperative crush cytology and later confirmed on histopathology. Papillary meningioma possesses characteristic cytological features. Along with the cellular meningothelial features, radial arrangement of cells around thin and thick walled hyalinised blood vessels gives the diagnostic clue. In addition, knowledge of clinical and radiological features is extremely helpful to arrive at the correct diagnosis and to differentiate it from other papillary lesions involving central nervous system. Due to aggressive clinical course and poor prognosis of papillary meningioma, a timely recognition of the diagnosis is desirable and helpful for rationalizing approaches to therapy.
Insights
Papillary meningioma, a rare WHO grade III tumor, shows distinct cytological features. Early diagnosis via intraoperative crush cytology aids in managing this aggressive brain tumor.
Area of Science:
- Neuro-oncology
- Cytopathology
Background:
- Papillary meningioma is a rare, aggressive WHO grade III variant of meningioma, characterized by high recurrence and metastasis rates.
- While histopathology is documented, cytomorphology of papillary meningioma is infrequently described.
Observation:
- This report details a case of papillary meningioma diagnosed using intraoperative crush cytology, subsequently confirmed by histopathology.
- Characteristic cytological findings include meningothelial features and a unique radial cell arrangement around hyalinized blood vessels.
Findings:
- Intraoperative crush cytology can accurately diagnose papillary meningioma.
- Distinct cytological features, particularly the vascular arrangement, are key diagnostic clues.
Implications:
- Timely recognition of papillary meningioma through cytological evaluation is crucial for effective therapeutic strategies.
- Integrating cytological findings with clinical and radiological data improves diagnostic accuracy and differentiation from other CNS papillary lesions.
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