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Updated: Jan 25, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
Published on: January 22, 2016
Associations between sociodemographic characteristics and substance use disorder severity among methamphetamine-using
Kaston D Anderson-Carpenter1,2, Jesse B Fletcher3, Dallas Swendeman1,4
1a David Geffen School of Medicine , Semel Institute for Neuroscience and Human Behavior, University of California , Los Angeles , CA , USA.
Abstract:
Background: Men who have sex with men (MSM) have elevated rates of substance use disorders (SUDs) and differences across sociodemographic sub-groups of MSM are associated with a greater risk of deleterious outcomes. Although studies have shown that MSM report greater rates of polysubstance use relative to other adult populations, the associations between sociodemographic characteristics and both acute substance use and substance use severity among methamphetamine-using MSM are unknown. Objectives: The present study examines associations between sociodemographic characteristics and (a) recent substance use and (b) SUD severity. Method: From March 2014 to January 2016, 286 methamphetamine-using MSM were recruited to complete a baseline Audio Computer-Assisted Self-Interview (ACASI) assessment and the SCID MINI. Multivariable analyses employed generalized structural equation modeling given the non-continuous nature of the endogenous variables. Results: All measured sociodemographic characteristics except gay self-identification were significantly associated with recent substance use (all ps ≤ .05), and all characteristics except current homelessness were significantly associated with diagnostic SUD severity (all ps ≤ .05). However, nuanced risks were observed in participants' use of specific substances regarding recent substance use and substance use severity. Conclusion: These results suggest that multiple factors contribute to the risks of SUD severity among methamphetamine-using MSM. As such, these results are useful in the tailoring of clinical and psychosocial intervention strategies that serve this and other high-risk populations.
Insights
Sociodemographic factors significantly impact substance use and severity among men who have sex with men (MSM) using methamphetamine. Understanding these links is crucial for developing targeted interventions for this high-risk group.
Area of Science:
- Public Health
- Addiction Medicine
- Sociology
Background:
- Men who have sex with men (MSM) exhibit higher rates of substance use disorders (SUDs).
- Sociodemographic variations within the MSM population correlate with increased risks of adverse health outcomes.
- Limited understanding exists regarding the link between sociodemographics and substance use patterns in methamphetamine-using MSM.
Purpose of the Study:
- To investigate the associations between sociodemographic characteristics and recent substance use among methamphetamine-using MSM.
- To examine the relationship between sociodemographic factors and the severity of SUDs in this population.
Main Methods:
- A cohort of 286 methamphetamine-using MSM completed baseline assessments using Audio Computer-Assisted Self-Interview (ACASI) and the SCID MINI.
- Data were collected between March 2014 and January 2016.
- Generalized structural equation modeling was utilized for multivariable analyses due to the non-continuous nature of the outcome variables.
Main Results:
- Most sociodemographic characteristics were significantly associated with recent substance use (p ≤ 0.05), with gay self-identification being an exception.
- Nearly all sociodemographic factors, excluding current homelessness, showed significant associations with diagnostic SUD severity (p ≤ 0.05).
- Specific nuances in substance use and severity risks were identified based on individual sociodemographic profiles.
Conclusions:
- Multiple contributing factors influence SUD severity risks in methamphetamine-using MSM.
- Findings underscore the importance of tailored clinical and psychosocial interventions for this population.
- The study provides valuable insights for public health strategies addressing SUDs in high-risk groups.
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