[Perioperative inflammation]
J Rossaint1, A Margraf2, A Zarbock2
1Klinik für Anästhesiologie, operative Intensivmedizin und Schmerztherapie, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, Gebäude A1, 48149, Münster, Deutschland. rossaint@uni-muenster.de.
Der Anaesthesist
|May 12, 2019
Summary
Surgical procedures and anesthesia can cause harmful inflammatory responses. Understanding these perioperative immune reactions and their triggers is key to improving patient outcomes and preventing tissue damage.
Area of Science:
- Anesthesiology
- Immunology
- Surgical Inflammation
Background:
- Surgical interventions and invasive procedures can trigger inflammatory responses.
- Stimuli include surgical trauma and anesthetic agents.
- This inflammatory response is a natural bodily defense mechanism.
Purpose of the Study:
- Identify causal factors of perioperative immune reactions.
- Present interventional options for managing inflammation.
- Discuss the impact of perioperative inflammation on patient health.
Main Methods:
- Conducted an extensive MEDLINE search.
- Focused on perioperative and postoperative inflammatory response.
- Included clinical and basic research.
Main Results:
- Overshooting inflammatory responses can negatively impact surgical patients.
- Anesthetic agents and surgical trauma modulate perioperative inflammation.
- Supportive therapy can influence inflammatory processes.
Conclusions:
- Perioperative inflammation has multifarious effects on patients.
- Immunomodulatory effects of perioperative therapeutics and anesthetics are highlighted.
- Knowledge aids informed decisions to improve patient outcomes.
