Related Experiment Video

Updated: Jul 9, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.5K

[Psoriasis and the microbiome]

M Witte1, D Thaçi2

  • 1Klinik für Dermatologie, UKSH Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Deutschland. mareike.witte@uksh.de.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|May 12, 2019
PubMed
Abstract

Insights

Changes in the skin and gut microbiome are linked to psoriasis development and progression. Analyzing the microbiome may help predict treatment responses in psoriasis patients.

Area of Science:

  • Dermatology
  • Immunology
  • Microbiome research

Background:

  • Psoriasis is a common chronic inflammatory disease with systemic effects.
  • Alterations in the microbiome are implicated in psoriasis onset and disease course.

Purpose of the Study:

  • To describe current methods for detecting microbiome changes.
  • To explore the role of the microbiome in psoriasis pathogenesis.

Main Methods:

  • Conducted a literature search using Medline and PubMed.
  • Included general internet and book research.

Main Results:

  • Both skin and gut microbiota influence psoriasis immunopathogenesis.
  • Antimicrobial peptides link microbiome and immune mechanisms in psoriasis.
  • 16S rRNA next-generation sequencing advances microbiome analysis.

Conclusions:

  • Microbiome analysis in psoriasis patients can identify biomarkers.
  • Biomarkers may predict individual treatment responses.
  • Microbiome data can guide treatment decisions for psoriasis.
Keywords:
Anti-infective agentsBiomarkersHigh-throughput nucleotide sequencingMicrobiomeMicrobiota

More Related Videos

Application of Flow Vermimetry for Quantification and Analysis of the Caenorhabditis elegans Gut Microbiome08:38

Application of Flow Vermimetry for Quantification and Analysis of the Caenorhabditis elegans Gut Microbiome

Published on: March 31, 2023

1.1K
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

785

Related Concept Videos

Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...
Dysbiosis of the Gut Microbiota01:18

Dysbiosis of the Gut Microbiota

The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...