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Research Progress of [68Ga]Citrate PET's Utility in Infection and Inflammation Imaging: a Review

Tingting Xu1, Yue Chen2,3

  • 1Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, No. 25, Taiping St., Luzhou, 646000, Sichuan, People's Republic of China.

Molecular Imaging and Biology
|May 12, 2019
PubMed

Imaging diagnosis of infection and inflammation has been challenging for many years. Infection imaging agents commonly used in nuclear medicine, such as [67Ga]citrate, 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), and radionuclide-labeled leukocytes, have their own shortcomings. Identification of a tracer with considerable economic benefit, high specificity, and low radiation dose has become clinically urgent. In the twenty-first century, with the increasing availability of positron emission tomography (PET) devices and the commercialization of Ge-68/Ga-68 generators, the study of [68Ga]citrate applications for infection and inflammation has increased and shown good potential. In this report, the research progress that supports [68Ga]citrate PET's applications various infectious diseases and inflammation is reviewed.

Keywords:
InfectionInflammationUtility[68Ga]citrate PET

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