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Updated: Jan 25, 2026
07:24
Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy
Published on: September 29, 2017
7.8K
Oxygenation of adipose tissue: A human perspective
Ioannis G Lempesis1,2,3, Rens L J van Meijel3, Konstantinos N Manolopoulos1,2
1College of Medical and Dental Sciences, Institute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham, UK.
Acta Physiologica (Oxford, England)
|May 12, 2019
Summary
Altered adipose tissue oxygenation in obesity may contribute to metabolic dysfunction and chronic diseases. Understanding oxygen levels in fat tissue offers a new strategy for treating obesity-related health issues.
Area of Science:
- Metabolic Physiology
- Obesity Pathophysiology
Background:
- Obesity is linked to adverse health effects, including cardiometabolic complications, largely due to dysfunctional white adipose tissue.
- Adipose tissue dysfunction involves adipocyte hypertrophy, impaired adipokine secretion, inflammation, and insulin resistance.
- Adipose tissue hypoxia has been proposed as a contributor to dysfunction, but human data are conflicting.
Purpose of the Study:
- To review the role of adipose tissue oxygenation in obesity-related complications, focusing on human studies.
- To overview determinants of adipose tissue oxygenation and its impact on glucose homeostasis, lipid metabolism, and inflammation.
- To discuss the effects of hypoxia on adipose tissue biology and whole-body metabolism in humans.
Main Methods:
- Review of existing human studies on adipose tissue oxygenation in obesity.
- Analysis of factors influencing adipose tissue oxygen levels.
- Examination of the relationship between oxygenation and metabolic parameters.
Main Results:
- Conflicting results exist regarding adipose tissue hypoxia's role in human obesity.
- Adipose tissue oxygenation influences glucose homeostasis, lipid metabolism, and inflammation.
- Hypoxia may impact adipose tissue biology and whole-body metabolism.
Conclusions:
- Altered adipose tissue oxygenation is implicated in metabolic homeostasis disruption.
- Targeting adipose tissue oxygenation presents a novel strategy for combating metabolic diseases in obese individuals.
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