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Emerging senolytic agents derived from natural products

Wen Li1, Lin Qin2, Rennan Feng3

  • 1School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan 650500, China; Department of Endocrinology, The Third People's Hospital of Yunnan Province, Kunming, Yunnan 650011, China.

Mechanisms of Ageing and Development
|May 12, 2019
PubMed

Insights

Cellular senescence, a key aging factor, involves cells that harm tissue repair and promote disease. Clearing these senescent cells (SCs) with senolytics, including natural compounds, shows promise for delaying aging and treating age-related conditions.

Area of Science:

  • Gerontology
  • Cell Biology
  • Pharmacology

Background:

  • Cellular senescence is a permanent cell cycle arrest linked to aging.
  • Accumulated senescent cells (SCs) impair tissue repair and drive age-related diseases via the senescence-associated secretory phenotype (SASP).
  • Evidence suggests SC clearance can extend healthspan and delay aging.

Purpose of the Study:

  • To review cellular senescence as a therapeutic target for age-related diseases.
  • To summarize natural compounds with senolytic activity.
  • To discuss the potential of these natural senolytics in clinical applications.

Main Methods:

  • Literature review of cellular senescence.
  • Analysis of senolytic compounds, focusing on natural products.
  • Examination of preclinical data for senolytic agents.

Main Results:

  • Senolytics selectively eliminate SCs.
  • Natural compounds like quercetin, fisetin, piperlongumine, and curcumin analogs exhibit senolytic properties.
  • Several natural senolytics have shown efficacy in animal models.

Conclusions:

  • Cellular senescence is a viable target for anti-aging interventions.
  • Natural compounds represent a promising class of senolytic agents.
  • Further research and clinical translation of natural senolytics are warranted.
Keywords:
AgingCellular senescenceNatural compoundsSenolytic agent

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