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Generation of Monoclonal Antibodies Against Natural Products
Published on: April 6, 2019
11.6K
Emerging senolytic agents derived from natural products.
Wen Li1, Lin Qin2, Rennan Feng3
1School of Pharmaceutical Science and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming, Yunnan 650500, China; Department of Endocrinology, The Third People's Hospital of Yunnan Province, Kunming, Yunnan 650011, China.
Mechanisms of Ageing and Development
|May 12, 2019
Summary
Cellular senescence, a key aging factor, involves cells that harm tissue repair and promote disease. Clearing these senescent cells (SCs) with senolytics, including natural compounds, shows promise for delaying aging and treating age-related conditions.
Area of Science:
- Gerontology
- Cell Biology
- Pharmacology
Background:
- Cellular senescence is a permanent cell cycle arrest linked to aging.
- Accumulated senescent cells (SCs) impair tissue repair and drive age-related diseases via the senescence-associated secretory phenotype (SASP).
- Evidence suggests SC clearance can extend healthspan and delay aging.
Purpose of the Study:
- To review cellular senescence as a therapeutic target for age-related diseases.
- To summarize natural compounds with senolytic activity.
- To discuss the potential of these natural senolytics in clinical applications.
Main Methods:
- Literature review of cellular senescence.
- Analysis of senolytic compounds, focusing on natural products.
- Examination of preclinical data for senolytic agents.
Main Results:
- Senolytics selectively eliminate SCs.
- Natural compounds like quercetin, fisetin, piperlongumine, and curcumin analogs exhibit senolytic properties.
- Several natural senolytics have shown efficacy in animal models.
Conclusions:
- Cellular senescence is a viable target for anti-aging interventions.
- Natural compounds represent a promising class of senolytic agents.
- Further research and clinical translation of natural senolytics are warranted.
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