Evaluation of the solid state form of tadalafil in sub-micron thin films using nanomechanical infrared spectroscopy

Assessing physical stability of drugs is important both in the development as well as in the production phase in the pharmaceutical industry. We used nanomechanical infrared (NAM-IR) spectroscopy based on photothermal response of a nanomechanical resonator, to investigate the solid state forms of tadalafil (TAD), under various storage conditions in sub-micron thin films. The amorphous TAD was stable, when kept at normal storage conditions of 24 °C, 45% relative humidity (RH) and shielded from light, however, it crystallized after four days when it was at stress storage conditions (40 °C, 70% RH, and direct sunlight). Additionally, we found that the signals recorded with NAM-IR were comparable with the attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and that NAM-IR proved to be a suitable and time efficient method when evaluating TAD in sub 500 nm layers.